Moving personalized medicine forward for every child with cancer, at Children’s Hospital Colorado and beyond

Lia Gore, PhD Center for Cancer and Blood Disorders, Children’s Hospital Colorado Dr. Lia Gore is the Section Head for the Center for Cancer and Blood Disorders at Children’s Hospital Colorado. In addition to her role as the Section Head of Hematology / Oncology / BMT-Cell Therapy at Children’s Colorado, Dr. Gore is also the…


The evolution of genetic sequencing: from “chips” to RNA sequencing and single-cell analysis

Andrew Donson, Senior Research Associate The Morgan Adams Foundation Pediatric Brain Tumor Research Program at the University of Colorado Anschutz Medical Campus & Children’s Hospital Colorado Andy Donson has been an integral member of the research team since the lab first opened its doors more than 25 years ago. “I was a biochemistry major in…


Colorado researchers taking two-pronged approach in search for new AT/RT cancer treatments

Generally, there are two ways to discover a new cancer drug: You can use basic science to discover a cancer’s Achille’s heel and then find or build a drug that exploits it, or you can try a bunch of drugs on cancer cells and see what works. Think of the basic science approach as building…


Your support funds research to stop cancer treatments from causing more cancer

Children’s Hospital Colorado oncologist Adam Green, MD, understands the risks of whole-brain radiation, but sometimes it’s an important part of the cure for cancers like medulloblastoma or high-risk leukemia. The problem is that in addition to the long-term cognitive challenges that can accompany this use of radiation, the treatment can actually cause new cancers: About…


Research identifies ‘genetic switch’ that may protect brain cancer stem cells

Chemotherapy and radiation kill rapidly dividing cells, a hallmark of cancer (and hair). However, cancer stem cells do not divide rapidly and so tend to resist these treatments. And while these stem cells make up only a small percentage of a tumor’s bulk, if only a small population survives treatment, they can often regrow a…


MAF Researchers secure federal grants and publication

There was quite a lot for researchers in the Morgan Adams Foundation Brain Tumor Research Program to celebrate in February! Dr. Nick Foreman’s group was awarded TWO large federal grants to continue their industry-leading research of ependymoma. First, an RO1 from the National Institutes of Health (NIH) / National Cancer Institute (NCI) will support an…


New cancer drug shows promise in treating deadly pediatric brain tumors

High-grade glioma (HGG) is the leading cause of cancer death among children. HGGs are fast-growing tumors in the brain or spinal cord that arise from glial cells. Glioblastoma (GBM) and diffuse midline glioma (which includes most diffuse intrinsic pontine gliomas or DIPGs) are two types of high-grade glioma most often seen in children. Led by…


World Cancer Research Day

[Dr. Sidney Farber] was convinced that the only thing standing between science and a cure for cancer was sustained research, sufficient funding, and the national will to bring it about. [1] When he was a pathologist at Boston’s Children’s Hospital in the mid-1940s, nearly all children with leukemia died — often painfully and within weeks…


International collaboration enables MAF researchers to apply for grant worth $9.6 million

Nick Foreman, MD, the Seebaum-Tschetter Chair of Pediatric Neuro-Oncology at Children’s Hospital Colorado, has been leading the way in moving groundbreaking kids’ cancer research from the lab to the clinic in Colorado for more than two decades.  Dr. Foreman’s prescient decision to collect and store tumor samples means the Morgan Adams Foundation Pediatric Brain Tumor…


RESEARCHER SPOTLIGHT Adam Green, MD

Dr. Adam Green joined the neuro-oncology group at Children’s Hospital Colorado in 2014. He has a dual role – caring for patients at Children’s Hospital Colorado in the pediatric neuro-oncology department and conducting research for The Morgan Adams Foundation Pediatric Brain Tumor Research Program. His goal is to develop better treatments, and ultimately a cure,…