Projects Funded This Year
From February 2001 to December 2021, The Morgan Adams Foundation has provided nearly $8 million in research funds for pilot, seed, and translational studies.
“The crucial support from Morgan Adams continues to fund all those high-risk, high-reward studies that would otherwise not be possible,” said Rajeev Vibhakar, MD, PhD and Program Leader of Pediatric Neuro-Oncology at the University of Colorado School of Medicine and Children’s Hospital Colorado. “It is these studies that often lead to novel, groundbreaking research projects and subsequent therapeutic interventions.”
2022 Projects Funded
Omics “in the round”
Nicholas Foreman
Bioinformatic analysis
Nicholas Foreman, Rajeev Vibhakar
Preclinical in-vivo testing of experimental therapeutics in ependymoma
Nicholas Foreman
Development of humanized immune system PDX model for evaluating the tumor-immune interaction in pediatric brain tumors
Nicholas Foreman, Andrea Griesinger
NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors: spatial transcriptomics to determine methods disease progression and transformation
Nicholas Foreman
Identification and validation of novel targets identified from the CRISPR druggable target screening in both H3K27M and WT histone-DIPG
Sujatha Venkataraman, Adam Green, Rajeev Vibhakar
Targeting Radiation Resistance in medulloblastoma
Bethany Veo, Rajeev Vibhakar
Synthesis and testing of humanized CD99 antibody with the novel 10D1 clone sequence in DIPG
Sujatha Venkataraman, Rajeev Vibhakar
Pre-clinical testing of novel gene-edited CAR-T cell therapy targeting pediatric tumors, DIPG, and Ewing Sarcoma
Sujatha Venkataraman
Analysis of stem cell and immune cell populations in pediatric high-grade glioma
Adam Green
Demonstrate the Impact of MMP-9 Knockdown in 3 Novel Adamantinomatous Craniopharyngioma (ACP) Models
Todd Hankinson
Multiplex Immunofluoresence spatial distribution in Adamantinomatous Craniopharyngioma (ACP)
Todd Hankinson
Mechanisms of BMI1 regulation in ATRT
Irina Alimova, Rajeev Vibhakar
Evaluation of autophagy inhibition clinical trial samples to assess biologic markers of response
Jean Mulcahy-Levy, Masanori Hayashi
Expanded application of zotiraciclib to pediatric brain tumors
Nathan Dahl
Development of Chimeric Antigen Receptor expressing macrophages to target pediatric brain tumors
Siddhartha Mitra, Sujatha Venkataraman, Mark Eric Kohler
Preclinical testing of the small molecule inhibitors Navitoclax, and Binimetinib using ex vivo Adamantinomatous Craniopharyngioma Tissue
Todd Hankinson
Combining radiation therapy with PRMT5 inhibition in diffuse midline glioma
Adam Green
CDK8 as a regulator of Myc driven Medulloblastoma
Dong Wang, Rajeev Vibhakar
Neurocognitive Function in the Pediatric Hematology, Oncology Population
Claire Fraley
Prospective Investigation of Childhood Cancer Early Death & Its Potential Causes
Adam Green
Development of a public web-based tool to refine interpretable AI tools in pediatric neuro-oncology
Todd Hankinson
Functional screening of pediatric high-grade glioma and radiation-induced glioma patient-derived models
Sujatha Venkataraman, Adam Green
Translating discoveries from brain tumor genomics into new therapeutic strategies
David A. Solomon
Identifying novel targets for MYC amplified Osteosarcoma
Masanori Hayashi
Utilization of Single Cell Analysis Tools to Identify Targetable Phenotypes for Pediatric AML
Amanda Winters
Myeloid Cell Phenotype in the Setting of Chimeric Antigen Receptor T-cell Therapy
Hannah Lust
Inhibition of multi-functional BETs in relapsed and metastatic osteosarcoma
Pankita H. Pandya
Institutional Partners
- Children’s Hospital Colorado – Denver, Colorado
- Alberta Children’s Hospital – Calgary, Alberta, Canada
- Boston Children’s Hospital – Boston, Massachusetts
- Children’s Health – Dallas, Texas
- Children’s Mercy Hospital – Kansas City, Missouri
- Children’s Minnesota – Minneapolis, Minnesota
- The Hospital for Sick Kids – Toronto, Ontario, Canada
- Johns Hopkins – Baltimore, Maryland
- Lurie Children’s Hospital – Chicago, Illinois
- MD Anderson – Houston, Texas
- Memorial Sloan Kettering Cancer Center – New York, New York
- Orlando Health Arnold Palmer Hospital for Children – Orlando, Florida
- Phoenix Children’s Hospital – Phoenix, Arizona
- Riley Children’s Health – Indianapolis, Indiana
- UCL Great Ormond Street Institute of Child Health – London, UK
- University of California, San Francisco – San Francisco, California
- University of Colorado Anschutz Medical Campus – Aurora, Colorado
- University of North Carolina, Chapel Hill – Chapel Hill, North Carolina
- University of Texas Health Science Center – Houston, Texas