Projects Funded This Year
From February 2001 to December 2022, The Morgan Adams Foundation has provided nearly $9 million in research “seed funding” for novel bench science studies. That funding has enabled an additional $17 million in partnership and follow on grants.
“The crucial support from Morgan Adams continues to fund all those high-risk, high-reward studies that would otherwise not be possible,” said Rajeev Vibhakar, MD, PhD and Program Leader of Pediatric Neuro-Oncology at the University of Colorado School of Medicine and Children’s Hospital Colorado. “It is these studies that often lead to novel, groundbreaking research projects and subsequent therapeutic interventions.”
2023 Projects Funded
CDK12 links radiation response to PARPi sensitivity in glioma
Nathan Dahl
Combinatorial targeting of transcriptional processivity in DIPG
Nathan Dahl
Pilot of Cell-Free DNA Testing in a National Pediatric HGG Trial
Adam Green
Single cell CiteSeq proteomic characterization of ependymoma infiltrating immune cells
Nicholas Foreman, Andrew Donson
Developing Models and Comparative Oncology Data for Canine and Pediatric High-Grade Gliomas
Adam Green, Steven Dow
Pilot Investigation to Characterize the Response of ACP Culture Models to Hypoxia
Todd Hankinson
Chromosome 1q and 6q changes as drivers of ependymoma recurrence
Nicholas Foreman, Andrew Donson
Spatial transcriptomic analysis of childhood brain tumor medulloblastoma
Nicholas Foreman, Andrew Donson
NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors: addressing MPNST tumor heterogeneity to identify novel therapy options
Nicholas Foreman
Omics “in the round”
Nicholas Foreman
Development of Chimeric Antigen Receptor expressing macrophages to target pediatric brain tumors
Siddhartha Mitra, Sujatha Venkataraman, Eric Kohler
Evaluation of frozen apheresis products for tumor cell contamination
Jean M. Mulcahy Levy, Anan Nellan, Siddhartha Mitra
Identify high affinity EFNA1 variants for immunotherapy against DIPG tumors that harbors wildtype histone H3
Sujatha Venkataraman, Siddhartha Mitra, Krishna Madhavan, Kristofer Fritz
Novel CAR-T cell therapies to circumvent the highly immunosuppressive ependymoma tumor microenvironment
Sujatha Venkataraman, Andrew Donson, Anandani Nellan, Andrea Griesinger, Nicholas Foreman
Continuing Investigation of Childhood Cancer Early Death and Its Potential Causes
Adam Green
Counterfactual Explanations of AI Predictions with Uncertainty to Improve Non-Invasive Diagnostic Accuracy of Pediatric Suprasellar Tumors
Todd Hankinson, Carsten Görg
Characterization of Cancer-associated Fibroblasts derived from Adamantinomatous Craniopharyngioma
Todd Hankinson
Piloting Key Correlative Studies in a National Pediatric HGG Trial
Adam Green
Spatial Transcriptomics in Pediatric High-Grade Glioma
Adam Green
Integrating single cell RNA sequencing with Visium data to identify the radiation resistance population of cells in DIPG tumors
Andrew Donson, Sujatha Venkataraman
IDH1 as a regulator of radiation resistance in Medulloblastoma
Bethany Veo, Rajeev Vibhakar
Regulation of Wnt by CDK11 in Myc medulloblastoma
Dong Wang, Rajeev Vibhakar
PARP inhibition in ATRT and Medulloblastoma
Irina Alimova, Breaunna Brunt, Rajeev Vibhakar
Single Nuclei Multiomics to identify mechanisms of oncogenesis in ATRT
Rajeev Vibhakar
Combinatorial targeting of CDK7 and antimetabolites for ATRT
Jean Mulcahy Levy
BioInformatics
Rajeev Vibhakar
Targeting an Oncogenic Driver in Infant Acute Lymphoblastic Leukemia: Bedside to Bench Correlative Studies
Kelly Faulk, Patricia Ernst
Translating discoveries from brain tumor genomics into new therapeutic strategies
David Solomon
DDRFA Round 1 Grant Funding
Adam Green
Institutional Partners
- Children’s Hospital Colorado – Denver, Colorado
- Alberta Children’s Hospital – Calgary, Alberta, Canada
- Boston Children’s Hospital – Boston, Massachusetts
- Children’s Health – Dallas, Texas
- Children’s Mercy Hospital – Kansas City, Missouri
- Children’s Minnesota – Minneapolis, Minnesota
- The Hospital for Sick Kids – Toronto, Ontario, Canada
- Johns Hopkins – Baltimore, Maryland
- Lurie Children’s Hospital – Chicago, Illinois
- MD Anderson – Houston, Texas
- Memorial Sloan Kettering Cancer Center – New York, New York
- Orlando Health Arnold Palmer Hospital for Children – Orlando, Florida
- Phoenix Children’s Hospital – Phoenix, Arizona
- Riley Children’s Health – Indianapolis, Indiana
- UCL Great Ormond Street Institute of Child Health – London, UK
- University of California, San Francisco – San Francisco, California
- University of Colorado Anschutz Medical Campus – Aurora, Colorado
- University of North Carolina, Chapel Hill – Chapel Hill, North Carolina
- University of Texas Health Science Center – Houston, Texas
