Projects Funded This Year
“The crucial support from Morgan Adams continues to fund all those high-risk, high-reward studies that would otherwise not be possible,” said Rajeev Vibhakar, MD, PhD and Program Leader of Pediatric Neuro-Oncology at the University of Colorado School of Medicine and Children’s Hospital Colorado. “It is these studies that often lead to novel, groundbreaking research projects and subsequent therapeutic interventions.”
2020 Projects Funded
RNASeq “in the round”
Nick Foreman
Creation of a single-cell atlas of pediatric brain tumors (year 2 of 2)
Nick Foreman
Pre-Clinical modeling of drug efficacy in pediatric brain tumors
Rajeev Vibhakar
High-throughput drug screening in pediatric brain tumors for rapid clinical translation
Nicholas Foreman
Rational approach to combined targeting of two major transcriptional regulators, EZH2 and CDK9 in MYC-medulloblastoma
Rajeev Vibhakar
Investigate the molecular pathways regulated by the oncogenic MIC2 in driving H3K27M-DIPG tumorigenesis
Sujatha Venkataraman
Developing a Clinically Translatable Interpretable 3D Radiographic and Transcriptomic Joint Domain Deep Learning Framework for Limited Datasets Using Adamantinomatous Craniopharyngioma as an Example
Todd Hankinson
PRMT5 Inhibition in Pediatric High-Grade Glioma
Adam Green
Development of Novel Therapies for Atypical Teratoid/Rhabdoid Tumors
Jean M. Mulcahy Levy
Development of CAR T cells to target ependymoma and the tumor microenvironment
Anandani Nellan, Nicholas Foreman
Understanding the oncogenic role of BMI1 in ependymoma (EPN) PFA tumors at the single-cell transcriptional level
Sujatha Venkataraman, Andrew Donson, Nicholas Foreman, Rajeev Vibhakar
Development of Human Immune System Mouse Models of ATRTs
Siddhartha S. Mitra
Targeting Hes5 in Embryonal tumors with multilayered rosettes (ETMR)
Sujatha Venkataraman, Andrew Donson
EMT in Craniopharyngioma
Todd Hankinson
Investigation Toward a DIPG Combination Therapy Clinical Trial
Adam Green
Targeting BMI1 in AT/RT
Rajeev Vibhakar
Combinatorial Immunotherapy against High-Risk Medulloblastoma
Siddhartha S. Mitra
Tumor microenvironment (TME) Modifying Immunotherapy Combined with Tumor Neurosphere Vaccine for Pediatric High-Grade Glioma
Anandani Nellan, Adam Green, Steven Dow
Biomimetic Microenvironments to Model Leptomeningeal Metastasis in Pediatric Neuro-Oncology
Rachael Sirianni
Evaluating the Mechanism and Efficacy of Targeting the Replication Stress Pathway in Pediatric Osteosarcomas
Pankita H. Pandya
From February 2001 to December 2019, The Morgan Adams Foundation has provided more than $5.4 million in research funds for pilot, seed, and translational studies.
Institutional Partners
- Children’s Hospital Colorado – Denver, Colorado
- Alberta Children’s Hospital – Calgary, Alberta, Canada
- Children’s Mercy Hospital – Kansas City, Missouri
- The Hospital for Sick Kids – Toronto, Ontario, Canada
- Johns Hopkins – Baltimore, Maryland
- MD Anderson – Houston, Texas
- Memorial Sloan Kettering Cancer Center – New York, New York
- POETIC (Pediatric Oncology Experimental Therapeutics Investigators’ Consortium)
- University of North Carolina, Chapel Hill – Chapel Hill, North Carolina