Projects Funded This Year

 

 

“The crucial support from Morgan Adams continues to fund all those high-risk, high-reward studies that would otherwise not be possible,” said Rajeev Vibhakar, MD, PhD and Program Leader of Pediatric Neuro-Oncology at the University of Colorado School of Medicine and Children’s Hospital Colorado. “It is these studies that often lead to novel, groundbreaking research projects and subsequent therapeutic interventions.”

2020 Projects Funded

RNASeq “in the round”
Nick Foreman

Creation of a single-cell atlas of pediatric brain tumors (year 2 of 2)
Nick Foreman

Pre-Clinical modeling of drug efficacy in pediatric brain tumors
Rajeev Vibhakar

High-throughput drug screening in pediatric brain tumors for rapid clinical translation
Nicholas Foreman

Rational approach to combined targeting of two major transcriptional regulators, EZH2 and CDK9 in MYC-medulloblastoma
Rajeev Vibhakar

Investigate the molecular pathways regulated by the oncogenic MIC2 in driving H3K27M-DIPG tumorigenesis
Sujatha Venkataraman

Developing a Clinically Translatable Interpretable 3D Radiographic and Transcriptomic Joint Domain Deep Learning Framework for Limited Datasets Using Adamantinomatous Craniopharyngioma as an Example
Todd Hankinson

PRMT5 Inhibition in Pediatric High-Grade Glioma
Adam Green

Development of Novel Therapies for Atypical Teratoid/Rhabdoid Tumors
Jean M. Mulcahy Levy

Development of CAR T cells to target ependymoma and the tumor microenvironment 
Anandani Nellan, Nicholas Foreman

 

Understanding the oncogenic role of BMI1 in ependymoma (EPN) PFA tumors at the single-cell transcriptional level
Sujatha Venkataraman, Andrew Donson, Nicholas Foreman, Rajeev Vibhakar

Development of Human Immune System Mouse Models of ATRTs
Siddhartha S. Mitra

Targeting Hes5 in Embryonal tumors with multilayered rosettes (ETMR)
Sujatha Venkataraman, Andrew Donson

EMT in Craniopharyngioma
Todd Hankinson

Investigation Toward a DIPG Combination Therapy Clinical Trial
Adam Green

Targeting BMI1 in AT/RT
Rajeev Vibhakar

Combinatorial Immunotherapy against High-Risk Medulloblastoma
Siddhartha S. Mitra

Tumor microenvironment (TME) Modifying Immunotherapy Combined with Tumor Neurosphere Vaccine for Pediatric High-Grade Glioma
Anandani Nellan, Adam Green, Steven Dow

Biomimetic Microenvironments to Model Leptomeningeal Metastasis in Pediatric Neuro-Oncology
Rachael Sirianni

Evaluating the Mechanism and Efficacy of Targeting the Replication Stress Pathway in Pediatric Osteosarcomas
Pankita H. Pandya

From February 2001 to December 2019, The Morgan Adams Foundation has provided more than $5.4 million in research funds for pilot, seed, and translational studies.

Institutional Partners